Targeted therapy with tumour-associated macrophages (TAMs) has emerged as a new paradigm for immunotherapy of cervical cancer.

The biological macromolecule Nocardia rubra cell-wall skeleton (Nr-CWS) has wellestablished immune-stimulating and anti-tumor activities.

中重度宫颈糜烂患者96例，采取随机表法分为对照组和治疗组，每组48例。

采用双盲随机对照试验设计，将感染HPV患者随机分配入2个组，实验组30例，安慰剂组10例，分别使用Ｎr-CWS和赋形剂。

外用Nr-CWS治疗高危型HPV持续感染及宫颈癌前病变合并高危型HPV感染，临床疗效显著，患者可耐受，值得推广。

Nr-CWS 联合 IFNα-2b 可有效调节宫颈 HR-HPV 持续感染患者的机体免疫能力，并促进 HR-HPV转阴。

宫颈癌，也称为子宫颈癌，是发生在子宫颈部位的恶性肿瘤，是女性生殖道最常见的妇科恶性肿瘤。人乳头状瘤病毒（HPV）是该病发生的最主要危险因素。

The Nocardia rubra cell wall skeleton (Nr-CWS) for external use is an immune enhancer,which has been widely used in human cervix diseases such as cervical erosion, but the mechanism of Nr-CWS enhancing immunity is still unclear.

探讨红色诺卡菌细胞壁骨架（Nr-CWS）对中性粒细胞生物学功能的调节作用及机制。